At later stages of development (>E8), however, network activity is driven by glutamate and GABA suggesting that there is a developmental switch in neurochemical transmission in the spinal cord [12].
A developmental switch in expression then occurs in which VGLUT2 is downregulated and VGLUT1 is up-regulated to become the predominant VGLUT in the hippocampus in adulthood [ 29, 30].
This synapse undergoes a "developmental switch" in which the dominant presynaptic mGlu expressed in these presynaptic terminals shifts from mGlu8 at early developmental stages to mGlu7 in adult rats.
These data may also support a developmental switch in the control strength of mitochondrial transfer RNAs and, in particular, mt-tRNAGlu in mitochondrial translation, suggesting that 16 30% steady-state levels of mt-tRNAGlu may have a profound effect on translation in muscle of neonates but may become less critical at later stages of development.
Interestingly, both transcription factors underwent substantial isoform transitions during thalamic development, suggesting a developmental switch in gene expression regulation by LEF1/TCF and β-catenin.
In honey bees, nutritional differences for larvae fed either royal jelly or worker jelly precede a developmental switch resulting in alternative caste phenotypes [ 26].
- This phytopathogenic fungus causes smut disease in corn.,, Important for infection is a developmental switch from saprophytic yeast cells, which proliferate by budding (Fig. 1A), to filamentously growing cells, the infectious form (Fig. 1B).
EUD-1 emerged following a lineage-specific duplication characteristic to Pristionchus, and executes a developmental switch for morphological plasticity in the adult stage, showing that regulatory pathways can evolve by terminal addition of new genes [ 37].
Only mouse Mbnl1, however, has been found to regulate a developmental switch from a foetal to adult-type alternative splicing pattern in a defined subset of pre-mRNAs [8].
