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This is the first report of a direct target of the mouse ataxin-3 DUB activity, and also the first report of the involvement of a DUB in a developmental process.
Though the embryonic expression of some of these molecules had previously been examined, frog metamorphosis allowed us the opportunity to see in particular how MT-MMPs and TIMPs might be regulated together in a developmental process that is controlled by one molecule T3.
In addition, EDM2 seems to have a WNK8-independent role in a developmental process related to vegetative phase change.
Unlike conserved miRNAs, only one of the highest expressed non-conserved miRNAs in pre-dormant leaves is known to play a role in a developmental process.
If each factor represents a true latent trait (e.g., variation in a developmental process), it is reasonable to decompose variation in this trait into genetic and environmental components.
These genes were chosen according to a differential regulation in crl1 mutant relative to wild-type, their molecular function or their putative role in a developmental process based on available literature data.
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More recently, apoptosis has been shown to act as a 'brake-release' signal during genitalia rotation in Drosophila, a developmental process that involves dramatic tissue rearrangement.
One plant gene may regulate a developmental process in response to heat while the exact same gene can regulate the exact same process but in response to cold.
Morphogenesis is a developmental process in which cells organize into shapes and patterns.
Generating and characterizing an allelic series of mutants defective in a particular developmental process is a common strategy to understand how genes control that particular process.
Our results indicate that a whole-organism RNA-seq approach, when combined with mutant analysis and functional validation, can be a powerful method to identify genes involved in a specific developmental process, in this case Q descendant posterior migration.
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