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Specifically, H3T3 is inserted in a defined structure within MLL1 SET domain.
If the antigen is in a defined structure like the nuclear pore complex, where each pore can only accommodate a defined number of proteins, increasing the amount of these proteins may lead to its mis-localization to the cytoplasm, ER or nucleus (Soderqvist et al. 1996; Bastos et al. 1996).
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This suggests that tandem membrane-anchored repeats of FM domains should mimic cadherin in producing a defined structure (staple) that will reversibly adhere intracellular membranes when it faces the cytoplasm, or in the present application produce intra-lumenal adhesions within Golgi cisternae when the FM repeats are lumenally-oriented.
Although in mCSM the pharmacophore is not described in terms of a defined structure of the mutant protein, there may still be further gains in the quality of the prediction if this could be incorporated into mCSM.
The foldon A-state monomer forms a β-hairpin with intact and stable H-bonds that is similar to the monomer in the foldon trimer, but lacks a defined structure in its N and C-terminal parts.
While this paradigm is true for many proteins, disordered proteins (i.e. proteins without a defined structure in isolation) can also be involved in complex interaction networks.
Structural studies on H-Ras indicate that the C-terminal segment lacks a defined structure in solution [16].
The C-terminal peptide of H-Ras does not show a defined structure in solution [16], but it adopts a precise conformation upon interaction with membranes [17].
In free play, the blocks are just there to play with, whereas in guided play, there is a defined structure to work towards and an assembly diagram.
Results from secondary structure predictions using Jpred (Cuff et al, 1998), Coils (Lupas et al, 1991), DisPredict-EMBL (Linding et al, 2003) and Foldingdex (Prilusky et al, 2005) indicate that residues after 245 in XLF may not have a defined structure (data not shown).
Since the purpose of the study was to identify in a defined structured form those clinical facts that influence conditional discharge, it would be self-defeating and probably impossible to blind clinicians and MHRB members to such unstructured information.
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