Sentence examples for in a defined context from inspiring English sources

Consequently, local changes to the epigenome can be observed, and transcriptional and epigenetic response to these changes can be studied in a defined context.

Taken together, this novel amputation strategy offers a defined context in which to measure and understand discrete changes in a stem cell population during regeneration.

Here, we were able to examine several lincRNAs and the regulation of the neighboring protein coding genes in a genetically defined context.

In a more spatially defined context, it has been demonstrated in the mouse that de novo crypt regeneration following injury is dependent on the confined induction of TGFβ expression.

30 32 We will identify explicit or implicit theories by which it is postulated how an intervention has an underlying causal mechanism that works in a defined social context to result in a particular outcome.

A better understanding of how uncapped telomeres are processed and ligated could unravel the mechanisms that sustain genomic stability in normal cells and could also provide a model to dissect DNA repair in a defined chromosomal context.

By using a large panel of well-characterized cancer cell lines or engineered isogenic cell lines that model the variability observed in patients in a defined genetic context, the goal is to systematically uncover genotype-dependent key cancer cell vulnerabilities.

Therefore, it might be rational to determine whether PRC2 is required for the differentiation and dedifferentiation of CSC (i.e. tumor cell plasticity), or for the epithelial mesenchymal transition, rather than modulating EZH2 levels to assess whether it is acting as an oncogene or a tumor suppressor in a defined cell context.

It has happened before, with Ian McKellen and Antony Sher: once you place Iago in a sharply defined military context you make him the play's pivot.

Although generally regarded as mechanistically similar, the effectiveness of Bcl-2 and Bcl-XL has not been compared in a single defined cellular context.

The SAR of an infectious disease quantifies the risk of disease transmission to an individual in the context of a defined exposure [1], [13].