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In a continuation study, we plan to conduct a real-life assessment related to forest bioeconomy activity and apply this study as the core for our indicators and tools to assess its sustainability.
Primary investigation on this plant has led to the isolation ofpolyphenolic acids, several flavonoids and monoterpenoids [3 6], and in a continuation study to obtain minor constituents, two new monocyclicmonoterpenoid glycosides, rel- (1R,2S,3R,4R p-menthane-1,2,3-triol 3-O β-D-glucopyranoside (1R,2S,3R,4R p-menthane-1,2,3-triol1R,2S,3R,4R p-menthane-1,2,3-triol (2) were obtained (Figure 1R,2S,3R,4R p-menthane-1,2,3-triol
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We now report the results of a continuation study in which patients who completed the 6-month extension study summarized above (Ketter et al. 2016) received up to 18 months of additional open-label treatment to evaluate the safety, tolerability, and effectiveness of long-term treatment with lurasidone.
Primary investigation on this plant has led to the isolation of several flavonoids, triterpene glycosides and ligans [3, 4], and in a continuation of studies on its minor constituents, the new natural product neohesperidin dihydrochalcone (1) and the known phloridzin (2), the first reported from the genus Oxytropis were obtained.
Patients in the continuation study had a baseline visit (corresponding to week 16 of the initial study) and 10 scheduled follow-up visits at weeks 4, 8, 12, 16, 29, 24, 28, 32, 36 (during treatment) and 40 (follow-up).
In the long-term extension of this phase IIb study [ 21] the investigators presented 12-month findings from patients who continued blinded therapy for an additional 6 months, but in this continuation study modification to methotrexate dose with/without change in DMARD was permitted.
Among patients who completed 12 months of treatment in the continuation study (N = 118;), mean change in weight and BMI was +1.8 kg and +0.7 kg/m2, respectively, with 16.1% having a weight gain of ≥7, and 5.9% having a weight loss of ≥7%.
Baseline demographic and clinical characteristics for patients in the current continuation study are summarized in Table 1.
In a continuation of this study, 27 pediatric acute leukemia patients were treated with a continuous infusion of 5-AZA-CdR at doses ranging from 37 to 80 mg/kg over 36 to 60 hours.
In a continuation of that study, we told a separate group of managers and contractors that they would have to justify their assessment of Chris to upper management.
In a continuation of our study on the chemical constituents of this species, we have examined the low polarity part of the EtOH extract of the titled plants.
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