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Engineering conformational stability requires the receptor to be trapped in a conformation induced by a test ligand to produce either an agonist or inverse agonist/antagonist conformation.
Maybe at pH 9.6, TcAAD exists in a conformation favors NAD+ over NADP+.
Each of three bound HBDs stabilizes the DnaB hexamer in a conformation that may increase its processivity.
Fusidic acid traps EF-G in a conformation intermediate between the guanosine triphosphate and guanosine diphosphate forms.
The filter is based on a geometric method called alpha shapes that captures the packing in a conformation.
Inter- and intra-molecular ionic interactions that occur at pH below 6.0 are proposed to trap the molecule in a conformation that allows its complete refolding upon cooling.
It appears that the two structures are in a conformation incompatible with repressor function, due to the presence in both proteins of fortuitous and structurally unrelated ligands.
This separation indicated that the activation has to proceed before the assembly to the mature complex, in a conformation where the ACP and PPT domains can meet.
Similar(3)
After 50 ns modeling, free r(I 10 (in A-conformation) was added to the system.
Before starting the simulation, the oligonucleotide (in A-conformation) was located near the nanotube surface.
The ratio of the bands' intensities 683/670 cm−1 is 1.3 (Table 3), which does not indicate the transition from the B-conformation DNA in A-conformation.
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