In fact, a common variant in GKRP reduces the risk of T2D (3).
19 In this scenario a common variant identified in the GWAS will be erroneously linked to a disease due to its chance association with the true causal variants which lie undetected by GWAS methodology.
They found a rare variant in a family with early onset macular degeneration in FBN2, but also a common variant in the same gene with a modest association to AMD cases.
In contrast, 607F is a common variant, present in ∼10% of the population.
In summary, we found that a common variant in the ABCC8 gene, Ser1369Ala, was significantly associated with the antidiabetic efficacy of gliclazide in nonobese type 2 diabetic patients in China.
For this reason, it is the most interesting finding in our present study that a common variant in the NLGN3 gene was identified to be strongly associated with susceptibility to male ASDs.
Five of these genes were also observed in a large GWAS reported from Iceland that also reported novel loci on 1q25, 3q27, and 12q13, 124 in addition to showing association with a common variant in the already established BDNF locus.
By analyzing the associations between array SNPs and deviations in BMD determined by DXA, we determined that a common variant in the 3′-flanking region of the GPR98 gene, rs10514346, is a candidate BMD-related polymorphism.
Our study shows a significant association between a common variant in TERC and TL in humans, suggesting that TERC may play a role in telomere homeostasis.
One of the largest ORs was 1.55 and was observed in nonobese patients with genetic polymorphism rs7903146 (T allele), a common variant in the TCF7L2 (transcription factor 7-like 2) gene (27).
