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Using PGS, which restricted analysis to multiple probes showing enrichment, the greatest degree of methylation in a characterized gene was HOXD9 (3.2 fold change across 8 probes).
We can compute these π j for any regulatory region given the numbers of each type of binding site in a characterized regulatory region (see Methods): where n j, f j and w j are the number of occurrences, specificity matrix and width of the j-th type of binding site, and P is a substitution matrix as above.
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They were married in 1973, in Wellfleet, Mass., in a ceremony characterized by the informality (the barefoot bride wore a granny dress and carried wildflowers) that seemed to characterize much of their marriage.
Part of this propensity to waste time this way is because we live in a society characterized by a gluttony of choice.
Numerous MMPs are expressed in the kidney in a poorly characterized and complex pattern.
It's refreshing to hear a critical voice in a body characterized these days by compliant Democrats and posturing Republicans.
For a man with a penchant for action, working in a Legislature characterized by paralysis and partisan stalemate can be deeply frustrating.
In a race characterized by one upheaval in the polls after another, Mr. Santorum's bubble may yet pop.
In a place characterized by topsy-turviness, why can't a celebrity also be a fan?
And that job is likely to take on even more visibility and importance in an environment characterized by a new mayor and new citywide officials.
Maybe they offer an illusion of permanence and continuity in a world characterized mainly by mobility, change, and uncertainty.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com