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Recruitment of the patient group was undertaken by inviting members of the Research User Group at the Arthritis Research UK Primary Care Centre and previous participants in a Centre study, to join the group.
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This figure is considerably lower than the 3.7% observed in the USA [ 6] and 8.6% in a single centre study conducted in a French ICU [ 18].
Data was collected in a multi centre study from a representative patient group of children and adolescents with cystic fibrosis.
Yet imaging examinations scored for study purposes are often evaluated by experienced observers (radiologists) in a single centre study.
This might be more likely in a single centre study, such as the one performed by Dr Sakr and colleagues, where transfusion decision-making was presumably more consistent.
In addition to the consideration of local factors and context that influence treatment outcomes in a single centre study, interpreting economic results also requires consideration of patterns of resource use and costs associated with a single centre.
"Then the wreck will be reconstituted and set up in a centre for study and preservation, where it can also be seen by the general public".
Another example in the field of pediatric oncology is the QLIC-ON software which has been successfully implemented and positively evaluated in a multi-centre study in the Netherlands [ 43] and includes a web-interface for data collection [ 44].
However, it is not possible to achieve double blinding to intervention by a MET in a single-centre study.
Machaalany et al. showed direct costs for investigating IF of ∼US $80 000 per patient in a single-centre study in Canada.
Pfizer paid funds to the University of Nottingham (i.e. not for personal gain) for work as a PI in a multi-centre study.
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