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In a big setback for Shell Oil, Coast Guard officials say that the Kulluk, a big offshore drilling rig, has run aground on an island in the Gulf of Alaska, Henry Fountain reports.
Aitor Karanka was left ruing his decision to send keeper Dimitrios Konstantopoulos up for a stoppage-time corner after Fulham scored a breakaway winner in a big setback to Boro's hopes of automatic promotion.
But now, in a big setback for Uruguay, ENCE, one of the two companies involved, has announced that it is abandoning construction of its plant on the contested border site, raising the prospect of renewed protests over the other factory.The project involves a total planned investment of $1.7 billion, representing 10% of Uruguay's GDP.
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Hooker is still a bit of a problem following the dumping of Dylan Hartley, and the recent defeat in a warm-up in Paris a big setback, but a place in the final is realistic.
In May, it suffered a big setback in China after the internet company Alibaba, in which Yahoo has a 43% stake, transferred one its key assets, Alipay, to a company controlled by its founder,Jack Ma.
That was the judgment of the highly respected anti-Taliban leader Abdul Haq, one of the many oppositionists who condemned the American bombing campaign launched in October 2001 as "a big setback" for their efforts to overthrow the Taliban from within, a goal they considered within their reach.
John Kerry doesn't seem to think that the outing of the CIA station chief in Pakistan will be "a big setback".
Yet, in truth, these elections were a big setback for both Mr Sarkozy and mainstream politics in France.Besides the low turnout, which itself reflects disillusion, three things stand out.
In 1999, that strategy suffered a big setback at the hands of AT&T, which beat out Comcast in a bidding war for another major cable operator, MediaOne.
My next venture was a securities trading company and produced the best return on investment in my career, so from a big setback came a great success.
The decline would indicate that a large number of institutional investors fear that stocks could suffer a big setback in the coming six months.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com