Serum anti-VEGF drug concentrations and plasma VEGF levels that were below the LLOQ were imputed to one-half the LLOQ value.
Before claiming that a patient's low level of PNa may be imputed to SIADH, one must keep in mind that various endocrine disorders induce hyponatremia the features of which may masquerade as SIADH, at least at first glance.
In the remaining 5% of cases, implant type was treated as missing and were imputed to fall in one of these groups.
With the highly accurate imputation method, each rice accession that had been sequenced at low coverage (onefold or even lower) was able to impute to over one million SNPs sites, which is much more cost-effective than high-coverage sequencing approach.
In the case of missing data in the PRO instruments, the mean of the completed items in one dimension was imputed to substitute the missing item provided that more than 50% of the items in one dimension were completed [ 31].
34 We applied multivariate imputation based on sex, age, ethnicity, socioeconomic status, health behaviours, body mass index, and biological markers at the preceding phase to impute missing values on health behaviours, body mass index, or biological risk markers at phases 3, 5, and 7. Twentypercentnt of the participants had at least one value imputed at one of the follow-ups.
Further, the imputation accuracy comparing SNPs imputed on one platform with SNPs genotyped on another platform was high, indicating that, with appropriate quality control, it is valid to combine imputed and genotyped SNPs in studies where samples have been genotyped either on the Affymetrix 6.0 or OmniExpress chips.
Thirdly, the response rate had to be imputed in one of the three studies [ 14] based on the panic frequency, which likely not reflect the whole panic disorder psychopathology.
Both imputation algorithms used here are restrictive in the sense that they force such missings to be imputed as one of the three habitual genotypes and do not account for the existence of null alleles or copy number variation.
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Excluding families that had imputed data on one or more family members (161 families) also made virtually no difference to the results (data not shown).
