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Data for subjects who discontinued during the nVNS treatment period were imputed to baseline values and were included in all efficacy analyses, whereas subjects with missing data for both study periods were not included in the analyses.
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The root cause never was imputed to the manufacturer.
A total of 16 (11.3%) FLACC scores were imputed at baseline, 19 (13.4%) at time of first injection, 6 (4.25%) at time of last injection, and 27 (21.1%) fifteen seconds after the last injection.
Since our analysis approach accounts for time at risk, the primary outcome of combined D2FS increment will be imputed from baseline to year 1 only for participants who failed to return for any annual visits, and the time-at-risk will be defined as the target date for the first annual visit.
The imputation process was applied to all baseline responders to impute baseline variables using appropriate distributions.
Four (15%) trials carried out simple imputation: two performed worst-case imputation and one imputed with baseline value.
Multiple imputation with chained equations was used to impute missing baseline demographic and clinical data [24].
The following covariates were included in this logistic regression model as they had been identified through univariate analyses to be associated with the outcome variable: English as the first language learned, education (those who had less than high school education), imputed baseline BPRS scores, and baseline self-reported diagnosis of schizophrenia.
Screening data were used to impute missing baseline data and vice versa.
As part of the study protocol, serum creatinine values were recorded for up to 48 h before study enrollment, which allowed us to use these serum creatinine values as baseline values and to calculate a rolling 48-h window for AKI ascertainment, rather than using an imputed baseline or nadir serum creatinine as baseline.
We imputed missing baseline data using regression or mean imputation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com