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To account for the additional variability of using an imputed risk factor, we used bootstrapping to estimate standard errors [ 16].
Furthermore, to extend existing GRSS methodology [ 44], count and weighted scores were constructed using probabilities of imputed risk alleles (p) by the equation below (Equation 1).
The analysis suggested that the imputed risk estimate was 0.95 (95% confidence interval 0.92 to 0.98), which is identical to our original risk estimate.
The genetic risk score was created by adding together the number of genotyped or imputed risk alleles of 30 genes or regions, thus assuming an additive model of inheritance.
This file provides tentative estimates of the regional population sizes of PWID and summarises reported new HIV diagnoses; raw data and with imputed risk group variable.
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The narrow time interval of 24 hours was chosen to minimize the risk for information bias and to be able to impute risk time information for exposed cases.
Theoretically, this may be justiï¬ed as (discriminatively) minimizing an imputed empirical risk.
The current BOADICEA web client makes this task laborious and time-consuming; each pedigree file must be free from errors, missing data may need to be imputed and risk estimates can only be requested for one member of one pedigree at a time.
To conduct the imputation, they fitted a working failure-time proportional hazards (PH) model to the midpoint imputed event time data to define an imputing risk set for each censored observation.
Using a validated formula, we converted both odds ratios into a relative risks and imputed the 5-10 yearisksk [ 21].
A few missing data were imputed, generating a risk of heterogeneity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com