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For dealing with missing values in microarry dataset, the overall imputed ratio by KNN algorithmis about 34% see Additional file 1.
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Inevitably we could not locate/calculate some unit costs within the available time and resources and we imputed these by calculating ratios of one unit cost against another within each site to account for differences in relative prices and then applying the average ratio across sites for the relevant service.
The typical methods for filtering poorly-imputed SNPs are using either the variance ratio or the imputed information score combined with minor allele frequency.
This software imputes missing logged ratio values before calculating s0, and this feature cannot be disabled.
Therefore, we increased our thresholds for variance ratio and the imputed information score in Table 3, and in Supplementary Tables S1 and S2.
Three patients receiving sugammadex had a measured (rather than imputed) time to a TOF ratio of 0.9 of >15 minutes.
We then calculated the serum 2-OHE1 : 16 α-OHE1 ratio using the imputed serum levels of 2-OHE1 and 16 α-OHE1.
Furthermore, we calculated the ratio between correctly imputed SNP genotypes and the number of non-missing genotypes for each chromosome using the "diff" and "lmiss" files implemented in Plink.
For the meta-analysis of GWAS, we included only imputed genotypes with imputation quality scores >0.6, where the score is defined as the ratio-of-variances (empirical/asymptotic) of each genotype.
S/F ratios categorized by the level of PEEP can be used to impute for P/F ratios in the calculation of the respiratory component of the SOFA score.
The rate ratios estimated on imputed data sets were pooled together using Rubin's rule to obtain valid statistical inferences (Rubin and Schenker, 1986).
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