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Although mortality data were used to create the imputed datasets, cases with imputed mortality data were excluded from the Cox regression analysis as recommended by von Hippel (25).
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Note that, in the multi-state model we are imputing mortality rates before first treatment.
In addition, we imputed missing mortality data and conducted a sensitivity analysis to assess the impact of missing mortality data on the mortality prediction of SHARE-FI.
For each of the two outcomes (breast cancer-specific mortality and overall mortality), 50 imputed datasets were generated and results were combined using the PROC MI and PROC MIANALYZE commands in SAS (version 9.3) with appropriate correction for variance.
In humans it is imputed to be a mortality cause in immunocompromised patients.
Data on mortality were imputed for those countries with little or no data by using data from other countries and were smoothed over time (in addition to other data corrections procedures that corrected for cause of death recording errors) (Lozano et al. 2012).
Missing data due to attrition (i.e., mortality, loss to follow-up, and refusal to participate) after randomization were imputed using multiple imputation [ 41, 42].
However, we have previously reported that estimates for the association between case mix variables and 30 day mortality, based on multiple imputed data, were verified by estimates based on complete case analysis.
Missing values were imputed using multiple imputations.
Mortality estimates for these areas were imputed using data from the Iraq Body Count to determine the ratio of death rates relative to other comparable high mortality provinces.
We applied the coefficients of the model developed in CRASH-2 with the estimated UK intercept to the five imputed datasets of TARN, obtaining five predictions of mortality for each patient in TARN.
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