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A sensitivity analysis was performed but imputed information was excluded, to verify that such imputation did not alter the estimated effect of adult weight gain and waist-to-hip ratio on mammographic density.
The typical methods for filtering poorly-imputed SNPs are using either the variance ratio or the imputed information score combined with minor allele frequency.
The two statistics most commonly used for this purpose are the variance ratio (rsq_hat in MACH [10] and the imputed information score (PROPER_INFO in SNPTEST) [5].
Therefore, we increased our thresholds for variance ratio and the imputed information score in Table 3, and in Supplementary Tables S1 and S2.
The result was similar with inflation of Type I error that is effectively filtered by IQS, whereas filtering by MAF and either the imputed information score or the variance ratio continue to have many false positive values (Table S2).
In the AA sample, IQS also acts as an effective filter and can be cautiously approximated by a combination of MAF and either the imputed information score or the variance ratio (Table S1).
Similar(47)
Applying equations 4 and 5 to impute information on cooking hours and ventilation, resulted in a modest adjusted r of 0.20 for cooking hours and predicted 30% of the "good", 90% of the "moderate" and 40% of the "poor" ventilation categories respectively.
We validated our imputations by comparing mean plant size and the overall size distribution in the population with and without imputed data [see Supporting Information—Table S1 ].
A series of analysis using imputed data for missing information on maternal blood pressure; varying the adjustment for maternal confounders such as gestational diabetes, maternal adiposity using pre-pregnancy BMI and rate of weight gain per week; and in a subgroup of women with peripheral systolic blood pressures less than 140 mmHg and diastolic blood pressures less than 90 mmHg.
We included imputed data for SNPs with quality information scores >0.3.
The imputed data are predicted based on known information of each individual [ 25].
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