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After filtering out valid imputations as defined in the methods section that were calculated in Steps 1 3, 228,437 imputed duration values for combinations of product, quantity, numeric daily dose and numpacks remained out of a possible 1,923,613 (11.9 % of imputations representing 3.1%% of all drug exposure data) that were possibly erroneous.
For all database records with a valid numeric daily dose (>0), 68.1 % of database records with imputed duration were equivalent to quantity/numeric daily dose and 74.7 % of database records had an absolute difference of no greater than 5 between quantity/numeric daily dose and imputed duration.
We also examined separately database records with a valid numeric daily dose (>0) to calculate proportions of database records with imputed duration equivalent to quantity/numeric daily dose and proportions of database records with absolute difference no greater than 5 between quantity/numeric daily dose and imputed duration.
Assessment of the lack of updating but use of imputed duration of hormone use among postmenopausal women showed modest attenuation over a 5-year follow-up interval in the NHS.
For validation purposes, we identified and examined problematic imputations after filtering out credible records with durations of 28 or 30, those with absolute difference no greater than 5 between quantity/numeric daily dose and imputed duration, and numeric daily dose = 0 (implies duration will be difficult to assess).
Similar(55)
Thus, we imputed drug duration for all exposures with invalid duration values of 0 (93 % of data) or >365 (0.0004 % of data) days.
We fit the base model using baseline variables and imputed HT duration without updating exposures and assessed covariates using the CTS comparing their magnitude and direction to the variables in the NHS.
If the pack size or daily dose were missing for a prescription then the duration was imputed from typical durations observed for that drug or drug class.
If instead of using observed updated data, we impute future duration of HT after menopause, the AUC c statistic is reduced modestly to 0.600 (s.e. 0.006).
Let \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hat{y}_{i1},\hat{y}_{i2}$$\end{document} = imputed estimate of duration of estrogen alone and duration of E&P, respectively, for the i th NHS woman.
Let \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hat{y}_{i1},\hat{y}_{i2}$$\end{document} = imputed estimate of duration of estrogen alone and duration of E&P, respectively, for the ith NHS woman.
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