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From the imputed proportions and their standard errors we calculated imputed differences (95% confidence intervals) in the prevalence of outcomes between 1995 and 2006 cohorts.
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Intention to treat analysis was based on complete datasets, given the problem of imputing modest differences for rapidly changing symptomatic outcomes.
Bimatoprost had a somewhat higher odds of achieving medication possession than travoprost when days supply was imputed, but this difference was significant (p = 0.048) only for the imputation method "2.0-2.1 Variable Factor".
The KS test was able to flag differences between the observations and imputed values; however, these differences did not always correspond to problems with MI inference for the regression parameter of interest.
For 39 trials (19.5%), we imputed the standardized difference in proportions (n = 25) or in means (n = 14) using additional information (such as the sample size or observed variance estimates; see Methods).
Third, we note that different imputed values can make a sizable difference in the estimated slope and the AIC.
Missing data were imputed using multiple imputations with differences in baseline quality of life and gender adjusted using regression techniques.
There were no differences between the imputed and non-imputed models describing the associations between SEP score and ST indicators, although the 95% CIs were slightly broader in the unimputed models due to the lower sample size (see online supplementary figure S2).
Furthermore, analyses without imputed values showed similar differences in AUC for pain intensity and satisfaction with pain relief.
We would not expect to get exact matches in many cases due to differences in imputed data.
Sensitivity analyses performed using data for which missing values were not imputed revealed no meaningful differences in results compared with those reported here for the imputed data.
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CEO of Professional Science Editing for Scientists @ prosciediting.com