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Missing data on demographic variables were imputed based on all other demographic variables, the counselor id-number and treatment status.
Missing demographic variables assumed invariant over time (e.g., ethnicity and gender) and logically structured over time (e.g., age) were imputed based on the available variable value at the observed assessment wave.
Respondents with two or less missing data points (n = 44) had values imputed based on their respective variable mode and respondents presenting with more than two missing data points (n = 7) were removed from further analyses.
Missing predictor values (2% of all required values) were imputed based on the correlation with the other predictor variables (He and Shen, 1997).
Missing prognostic and EQ-5 D data will be imputed, based on each patient's other prognostic characteristics.
For subtests in which a ceiling was not achieved (< 10%), missing values were imputed based on scores obtained by other children with similar score patterns.
If one of the four CAGE items was missing (N = 64; 0.8%), its value was imputed based on the mean of the three other answers.
In other cases it was imputed based on the most probable values (taking into account available data).
When either x i or y i is MAR and the other variable is < LOD, the < LOD value is imputed based on the estimated marginal distribution (a truncated univariate normal).
In the former, weights are imputed based on results from previous studies.
We assessed associations with other SNPs within 500 kb either side of rs1053338, both genotyped and imputed, based on BCAC iCOGS data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com