Concurrency was imputed as a binary outcome at 6 months before the survey for those with multiple partnerships in the past year [21].
Values below the LODs were assigned the machine-read value if a signal was detected and otherwise imputed at random based on a log-normal probability distribution whose parameters were determined using maximum likelihood estimation (Lubin et al. 2004).
If not, all concentration levels < LOD were imputed at random based on a log-normal probability distribution using maximum likelihood estimation (Lubin et al. 2004).
We then censor the viral load data at detection limit 25, producing totally 23percentt of below detection data which are imputed at 25 as observed in a real experiment.
Given this evidence, we decided to attempt replication of the best-associated markers (whether directly genotyped or imputed) at these 24 loci in an independent Spanish cohort (Phase II).
Missing values were imputed at the protein abundance level using a regularized expectation-maximization algorithm [ 25].
First, history of previous HIV testing based on transmission category and type of diagnosis was imputed; at the same stage, conditionally on a previous imputed negative test, time delay between the two tests was imputed using a linear regression model based on transmission category and type of diagnosis as described above and 5 datasets were generated.
We decided that when the value 1 (i.e. complaints) was imputed at least 6 times out of 10 for a particular patient, this patient would be considered as non-recovered.
Table 8 provides an illustration of the RICV imputed at $16.5 million.
All core analyses will be conducted with and without imputation for individual variables, including variables that will be imputed at the level measurement, that is, before aggregation to form hospital-level measures.
A total of 16 (11.3%) FLACC scores were imputed at baseline, 19 (13.4%) at time of first injection, 6 (4.25%) at time of last injection, and 27 (21.1%) fifteen seconds after the last injection.
