A $70 million deal would impute a value on all of ICTSI of over $280 million, more than four and a half times its current market cap.
The parameters of this model, which has a R2=0.25, were applied to the similar characteristics of patients in each of the condition episodes to impute a value of family income (Table 5).
For patients missing a left ventricular ejection fraction measurement (at present <1.5% missing), we will impute a value of 50%.
Health utility was estimated by applying tariff values to the EQ-5D responses or imputing a value of zero for those who had died.
The approach also imputes a value of eGFR at zero follow-up time (intercept) and a time to ESRD (whether observed or not).
The gestational ages for nine children were unavailable, and thus the mean of the remainder of the children was used to impute a value for these nine for purposes of the regression analysis.
The predicted value from a linear regression of observed data prior to a missed assessment was used to impute a value at the time of the missed assessment.
The values of insulin-like growth factor (IGF) 1 of 16% of the samples and the values of growth hormone (GH) of 6% of the samples, which were flagged as being below the detection limit, were imputed with a value of half of the lowest detected concentration.
Thus, any measured or calculated value of mutant or wild-type α-Gal A activity in the HEK-293 cell-based assay that was below this LOQ was imputed as a value of zero.
