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No attempt was made to impute outcomes for non-responders.
The completeness of data for each outcome was variable and as it is not recommended to impute outcomes, a complete case approach was adopted (n with complete data for all outcomes was 5684).
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This data attrition can be viewed as a missing data issue, and mixed effect modeling that we used in this study has been found robust in this setting [50], as they implicitly impute outcome trajectories beyond the time of death or extubation.
A clinically plausible amount could be added to or subtracted from imputed outcomes, possibly using a technique such as multiple imputation.
Data will be analysed with and without imputed outcomes.
The predicted outcome can be estimated as the average of the imputed outcomes.
However, it should be noted that imputing outcomes is intrinsically problematic.
In Section 3, we show is asymptotically unbiased for IPW/MI with linear regression and imputed outcomes.
9 Conversely, analysts could report how large an amount should be added to or subtracted from imputed outcomes without changing the clinical interpretation of the trial.
We used a conservative approach and imputed outcomes for the missing participants, assuming that they did not respond to treatment (Cipriani et al, 2009).
Table 2 shows survival and imputed outcomes at each gestational week and provides survival and disability estimates and ranges for births based on three clinically useful denominators.
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