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The data will be analysed on an intention to treat basis with all analyses including missing data by imputing change across time to be zero.
Using methods that imputed changes in medical expenditures from changes in utilization, the evaluations of Bank of America and CalPERS programs for seniors reported ROIs of approximately $5.00 to $1.00.
Input-output analysis is invoked to impute the change in this bundle to technical change, a terms-of-trade effect and two types of efficiency change.
To be conservative, we assumed a correlation of 0.5 to impute missing change variance estimates in the primary analysis.
The prespecified methodology imputed a change variable (mTSS progression) in a patient by replacing status variables (mTSS) across patients.
We imputed missing data at 2 years using the method of last observation carried forward [ 30] for measured variables, and imputed no change for self-reported behavioral change variables; and (3) by per protocol analysis defined in two ways: firstly, by whether subjects attended at least one of four educational session of the OPSMC, and secondly, by whether they attended all four OPSMC sessions.
We will impute BMI percentile change among attritors using their historical heights and weights obtained through chart review; however, we also will conduct treatment completer analyses using only complete cases.
As the effect sizes for the impact of interventions are expressed in standard deviation units, we could then impute the average change in disability weight given an effect size for each intervention.
The structural and morphological studies were done by means of EDX and SEM to investigate the structural change imputed by the clay incorporation and irradiation.
This analysis with missing data imputed did not change the overall results and is not presented.
* estimated between study variance Whatever the parameter of interest or the adjustment factor considered, the fact that variances were imputed did not change the conclusions.
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