Based on data imputation principles, together with several mathematical models, this paper presents a CCDSS, the Patient Oriented Method of Pain Evaluation System (POMPES), that produces tailored alarms, reports, and clinical guidance based on collected patient-reported data.
In principle, the imputation model should also contain the relevant interactions, but the specification of the imputation will become more cumbersome.
29 31 Analysis was performed according to the intention-to-treat principle, with imputation techniques adopted to address the issue of incomplete data.
In principle, most imputation methods could use this approach, and researchers can already download implementations based on the IMPUTE2 and MaCH models (the MaCH implementation is called "minimac").
All analyses will necessarily be based on the ITT principle; standard imputation methods (e.g., last observation carried forward) will be used to estimate missing data (withdrawal, failure to start) and data analysed according to initial group (random) allocation.
Estimation of a separate within-family component of the breeding value is based on the same principles as imputation [ 8], but skipping the imputation-step means that no animal needs to be high-density genotyped.
However, the properties of a method using the JAV principle with another imputation model are thus far unknown.
MissVIA is built up based on the easy-to-use principle, so every imputation task could be completed with only three steps: (a) upload the dataset with missing values, (b) choose the imputation algorihtms and (c) click the "Submit" button.
Our work was motivated by the idea that growing reference datasets need not make panel selection more difficult or force tradeoffs between imputation speed and accuracy; in principle, larger and more diverse reference collections could actually make it easier to identify haplotype sharing with simple models, thereby making imputation faster and more accurate.
