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Imputation of costs missing at the cost category level and of outcome data at the scale level was carried out using the MCMC multiple imputation package in SPSS v.19 (SPSS, Inc., Chicago, IL, USA) (Supplementary data are available in Age and Ageing online, file 6).
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Multiple imputation of missing costs with possibly zero values is more complicated, and two-part models can be more useful.
After multiple imputation of missing cost data, the average care costs were €14,286 per person per year in the pre-implementation PReCaP group and €21,251 per person per year in the post-implementation PReCaP group.
Imputation of missing cost data for medicine use increased the costs in the usual care group by €1.42 (SD = 4.45) and in the intervention group by €1.38 (SD = 4.25).
Imputation of missing cost data for medicine use and increasing the costs of private purchases of specific products/tools aimed at reducing neck, shoulder and arm symptoms in the sensitivity analyses did not change the conclusions of this economic evaluation.
The imputation of missing cost data led to a mean difference of €31.02 (95% CI -32.32 to 76.43) in total costs.
Our base case analysis included 135 women based on recommendations for multiple imputation of missing cost and HSUV data [ 35].
This comprehensive country adaptation and extension of the existing short-term Markov model [ 17] required much more than just the imputation of Spanish unit costs.
The accuracy of imputation and the costs per individual of each of these scenarios are shown in Table 4.
Finally, based on accuracy of imputation of several schemes, the costs of the more relevant of these alternatives were estimated.
Lastly, our study did not report explicit cost benefits by imputation strategies considering costs of bioinformatics and whole genome sequencing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com