Sentence examples for imputation of additional from inspiring English sources

In a case-control study of 1,161 type 2 diabetic patients and 1,174 control subjects, 3,531 variants in these 222 genes were genotyped and after imputation of additional variants, coverage of 99.9% of common HapMap variants was achieved.

Six tagging single-nucleotide polymorphisms (SNPs) of NFE2L2 were genotyped, and, after further imputation of additional 34 SNPs, association testing with ARDS susceptibility was conducted using logistic regression analysis.

Imputation of additional SNPs was done using MACH 1.0.16 (http://www.sph.umich.edu/csg/abecasis/MACH/index.html) and data from the full data set of HapMap phase 1 and 2 (http://hapmap.ncbi.nlm.nih.gov/).nih.gov/

We believe that this hypothesis is unlikely to underpin a substantial proportion of the multiple signals we have observed in this study, since 11 of the 16 identified complex regions had been densely genotyped on the iCOGS array, enabling very thorough imputation of additional untyped variants within the region.

These results were not appreciably changed after performing multiple imputation of missing data (Additional file 2).

We compare various estimates of health behaviour and risk that result from no imputation, standard demographic-based imputation and finally imputation that is based on the use of additional covariates in the survey.

Comparison of these results showed good agreement across the two imputation samples considered and we were confident that the estimates were not being overly impacted by noise due to imputation of the outcome (see Additional file 3).

Efficacy analyses were conducted in the intention-to-treat population (all randomly assigned and treated patients analysed in the arm they were randomly assigned to) with non-responder imputation for categorical variables (eg, DAS28 remission, ACR response), last observation carried forward until patient withdrawal for missing joint counts and no additional imputation of missing values.

Impute2 was the best software for imputation in our dataset and the inclusion of additional Warmblood reference sequences increased the accuracy of imputation furthermore.

To assess the influence of missing C. pneumoniae DNA status of sputum, imputation of one, three or seven additional sputum positives was performed, corresponding to the proportion of observed sputum DNA positives with 95% confidence interval among subjects who were PBMC DNA negative.

The resulting mismeasurement of imputed lab test results suggests that imputation of test results would provide only limited additional confounding control.