Exact(7)
As some of these regression variables were missing in the clinical data it was not possible to impute BMI for all patients; however, the imputation increased the BMI completeness rate from 36%to88%8%.
Imputation increased sensitivity on average from 48% to 53% for ASD status.
Lastly, in general, as the proportion (or number) of samples sequenced increased (i.e., larger set of reference haplotypes), the quality of the imputation increased.
For melanoma and prostate cancer, imputation increased numbers of Aboriginal cases by 92% and 31% respectively.
The performance of IMPUTE2 dramatically dropped off as the complexity of imputation increased (i.e. lower relationships to high density animals, lower density genotyping).
Imputation increased the SNP coverage to a total of 2067645 markers (Additional file 3: Table S1), though without direct scoring of SNPs that might have had higher p-values.
Similar(53)
In our simulation studies, we identified that the MNAR estimates were biased and did not converge to the true value of the parameters of interest for either the marginal mean of the outcome or the regression coefficient as the number of imputations increased.
In particular, increasing the number of imputations increases the chance of drawing an extreme imputed dataset that is assigned an extreme weight.
Similar to imputation in purebred Merinos, imputation accuracy increased when using a larger reference set.
Extremely low-coverage sequencing and imputation increases power for genome-wide association studies.
The accuracy of imputation increases with the number of SNPs in the test set for all the scenarios and the methods examined here.
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