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The principle is based on measuring the impulse flow colliding with the plate.
Finally, the facilitatory action of 5-HT4 receptor stimulation on 5-HT impulse flow permitted to unmask the effectiveness of a low dose of citalopram on postsynaptic targets.
Nonetheless, this proposal also entails summation between activity of pharmacological origin that is independent of the electrical stimulation and impulse flow driven by the electrode.
However, the question whether it would be possible to combine a direct enhancement of 5-HT neuronal impulse flow with the passive augmentation of 5-HT levels produced by conventional antidepressants still remains unanswered.
On average, 5-HT neuron impulse flow recovered up to 70% and 61% with respect to basal values, in the presence of fluvoxamine and citalopram respectively, after the administration of prucalopride (Figs. 1A and 1B).
In all the recorded cells, the intravenous injection of either fluvoxamine (350 µg/kg, n = 10) or citalopram (500 µg/kg, n = 11) strongly reduced 5-HT neuron impulse flow.
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The binding triggers a cascade of chemical reactions within the sensory cell that result in the production of nerve impulses flowing to the brain.
When the Mongol ruler Kublai Khan established the Yuan dynasty (1279-1368), pungent aesthetic impulses flowed in from all over Central and Western Asia, soaking into Chinese traditions, creating a hybrid art that became, and would remain, a new norm to be embraced or resisted.
If the nerve impulses flowing to the brain had also been included in the model then the electrical domain would have made four domains encompassed in the model.
Considering the above discussed relationship between efficacy of reuptake blockade and impulse-flow, it is therefore not surprising that the SSRI displayed a more consistent influence at the terminal level, and that its effect was not simply added to that of the agonist.
The length and color of a lobe on the circular pie diagram corresponds to the squared intensity of the impulse energy flow in a given angular sector.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com