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MS pathology consists of inflammatory demyelination of CNS axons causing neurological symptoms initially, when saltatory conduction for efficient nerve impulse conductance becomes compromised, and later compounded by the loss of metabolic support from myelinating oligodendrocytes leading to irreversible neurodegeneration.
Mature oligodendrocytes produce myelin, a lipid-rich membrane structure that insulates neuronal axons to both protect them and to aid in saltatory impulse conductance throughout the CNS (Griffiths et al., 1998).
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Myelin is a fatty substance which wraps itself around nerve fibres, preventing leakage of electrical current and facilitating the conductance of nervous impulse.
Two sensors attached to the fingers monitor pulse and skin conductance (sweat).
The importance of this association lies in the prominent causal role that has been attributed to nodal persistent Na+ conductances in generating ectopic impulse activity in the peripheral nervous system (10, 22).
Therefore, dantrolene can either ameliorate conduction depression by decreasing intracellular free Ca2+ concentration (to improve gap junction conductance) or further decelerate CV via prolonging APD (as impulses traveling through partially refractory tissue).
Skin conductance is a measure of the ability of sweat to conduct electricity.
A sensor measured "skin conductance" — palm sweat.
An impulse?
(Chinen) ★ Impulse!
Conductance changes can be measured.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com