Sentence examples for improving their potency from inspiring English sources

Thus, the replacement of the amino group by an acetic acid moiety changes their biological activity, improving their potency as ARIs.

Based on these results we hypothesize that an increase in the affinity of HwTx-IV for lipid membranes is accompanied by improved inhibitory potency at hNaV1.7 and that increasing the affinity of gating modifier toxins to lipid bilayers is a strategy that may be useful for improving their potency at hNaV1.7.

Like makers of drugs improving their potency, the techniques for triggering ASMR are getting more and more precise and elaborate at this point, fake haircuts with 3D mics are old news but that old question asked on the Society of Sensationalists group is still unanswered: What causes this?

This series of compounds were further optimized to improve their potency against PI3Kα and mTOR.

Using the structure of 4a as a starting point, a series of novel bis-1,2-benzisoselenazol-3(2H -ones was designed, prepared and tested to explore the structure–activity relationships (SARs) for this class of inhibitor and to improve their potency.

Crystal structures of several such Abs bound to gp120 [ 38, 40, 41] revealed molecular details of their neutralization mechanisms and facilitated structure-based rational design to improve their potency and breadth.

To improve their potency, we cultured TB6-2 cells on a gelatin-coated plate in 1000 U/ml LIF plus 15% Knockout Serum Replacement (KSR) medium, and they were maintained under "serum- and feeder-free" or "serum- and feeder-independent" conditions.

During typical lead optimization cycles in the discovery phase, the lead molecules undergo several chemical modifications in order to improve their potency and pharmacokinetic (PK) properties, which usually lead to increased a) molecular weight, b) lipophilicity, c) molecular complexity, d) number of rotatable bonds, e) number of H-bond donors and acceptors, etc.

The potential of recombinant plant cystatins as effective pesticidal proteins in crop protection is also considered, as well as protein engineering approaches adopted over the years to improve their inhibitory potency and specificity towards Cys proteases of biotechnological interest.

In addition, we have established a method for creating functional mutant proteins (muteins) with desired properties, and developed a site-specific polymer-conjugation method to further improve their therapeutic potency.

This question is particularly important if a decision were made to use medicinal chemistry to optimize cucurbitacin compounds as anti-cancer therapeutics by improving their on-target selectivity and potency while minimizing their reported toxicities [ 17].