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Although the beneficial effects of chaperones in preventing the aggregation and improving the trafficking of PMP22 have been repeatedly observed, the requirement for HSP70 in events remains elusive.
Improving the trafficking of the enzyme to lysosomes is an important therapeutic goal as (1) this organelle is the site of glycogen storage and (2) it is in the late endosomal/lysosomal compartment that GAA is processed into its 76 and 70 kDa mature and active isoforms.
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Wavelength converters and changing link weight help much in improving the traffic performance when the number of splitters is adequate.
In order to improve the trafficking of mutant ACE to the cell surface, we cultivated CHO cells expressing mutant and WT ACE in various conditions known to increase trafficking of proteins to the cell surface and prevent intracellular degradation.
CAR T cell therapy for prostate cancer holds promise, given that measures are taken to overcome the highly suppressive tumor microenvironment and to improve the trafficking of T cells toward bone metastases.
In 1962, Taylor's play AA Went Tae Blaydon Races, opened the new Flora Robson Theatre, later demolished for road improvements that haven't significantly improved the traffic flow.
The use of traffic control systems can potentially improve the traffic flows on traffic networks.
The hope is that this will improve the traffic flow on both avenues.
In "Traffic control", we use traffic light controls to improve the traffic diagram.
This project is to improve the traffic condition by controlling the traffic lights and hence benefits the public.
The company is also using vehicle data to improve the traffic flow of delivery vehicles and reduce delays.
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