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The pharmacological results suggest that the substituent groups are vital for improving the potency and selectivity of this class of compounds.
Although DNA immunogens have been shown to stimulate both the cellular and/or humoral arms of the immune system, improving the potency of these vaccines is clearly important.
Discovery of the novel scaffolds and binding mechanism suggests avenues for extending the interaction surface and improving the potency of a hydrophobic pocket binding inhibitor.
Thus, our study provides a new avenue for designing and improving the potency and selectivity of inhibitors against H3K9 Jumonji demethylases over H3K9 methyltransferases and H3K4 demethylases.
Microparticle-based delivery of nucleic acids has gained particular attention in recent years in view of improving the potency of DNA vaccination.
We revealed that a combination of our newly developed linker and hydantoin (54) plays a pivotal role in improving the potency and selectivity of LXRβ.
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It is natural, they said, to try to improve the potency of the tracking systems by integrating data from online and offline sources.
An obvious future direction is to improve the potency of these compounds against wild-type yeast.
New delivery technique including DNA transfer by electroporation recently greatly improved the potency of this concept.
To improve the potency of vaccines, immunostimulants targeting these PRRs are often used as adjuvants to activate and prepare the immune system for reacting to specific antigens.
Further substitution of Lys2 with Nle slightly improved the potency of the tetrapeptide, which selectively activates FPRL1 over FPR.
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