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Improving the affinity for alternative acceptors by means of enzyme engineering will, therefore, be a major challenge for the commercial exploitation of the transglucosylation potential of sucrose phosphorylase.
Tannins play very important role in dyeing with natural dyes by improving the affinity of fibres towards different dyes.
We found that, on average, the context is responsible for roughly 20% of the binding and plays a crucial role in determining interaction specificity, by either improving the affinity with the native partner or impeding non-native interactions.
Therefore, efforts can be made to modify PLLA using PEG, in order to make the hydrophobic surface more hydrophilic, and thus improving the affinity for proteins and cells.
Efforts have focused on improving the affinity of lead compounds that bind to the full extent of the dimer interface with a 1 modulator/dimer stoichiometry, in some cases using the properties of thiazides with 2 modulator/dimer stoichiometry.
The final four mutations filling the IFN γR1 cavities and potentially improving the affinity to IFN γ were expressed, purified, and refolded, and their affinity towards IFN γ was measured by SPR.
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Biol.], we describe engineering efforts to improve the affinity of mAb 5D3D11, a first step towards such goal.
In order to improve the affinity and activity of these HDACIs, twenty seven isoferulic acid derivatives were described herein.
To improve the affinity, yeast display of the 2C TCR was used to engineer two mutant TCRs that exhibited higher affinity for F5R Ld (KD = 1.2 and 6.3 μM).
Low pressure (LPP) and atmospheric pressure (APP) plasma were used to modify the surface properties of the organic polymers to improve the affinity for TiO2 aqueous sols and solutions.
These changes improve the affinity of the PE separators for polar liquid electrolytes and their ionic conductivities compared to those of bare PE and other ceramic-coated control systems.
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