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The design centres on the use of a custom-designed polymer optical element (POE), which obviates the need for optical fibres, thereby improving probe stability and rendering it more suitable for use outside a laboratory environment.
Triethylene glycol analogue 2 marked a modest first step in improving probe properties.
Interphase cell preparations were incubated at 37°C for 10 min and then treated with 300 μl ml−1 HCl pepsin, pH 2.7 3 (Sigma, Dorset, UK) at 37°C, to remove cytoplasmic proteins, hence improving probe penetration.
Several strategies could be developed to improve the detection specificity of microarrays, including improving probe design, hybridization conditions which would minimize the effects of cross-hybridization, as well as improving image analysis software/algorithms to facilitate more accurate signal quantification and detection thresh-holding.
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Current device developments for oral CM include improved probe design.
Furthermore, SWITCH synchronizes labeling reactions to improve probe penetration depth and uniformity of staining.
An improved probe technique for the measurement of bubble size and velocity in turbulent bubble dispersion has been developed.
This method provides AFM users improved probe quality and practical guidelines for customized probes, which can support the development of novel scanning probe microscopy (SPM) applications.
The increased refrigeration power available with this more complex cycle improves probe effectiveness by reducing the number of probes and the time required to treat large tissue masses.
A computational algorithm was generated to filter out the likely artifactual probes from existing whole-genome tiling array data and improve probe selection.
An improved probe design, based on the nearest neighbor model for nucleic acid-probe duplex stability, resulted in a better separation (ΔTm ∼ 10°C) of melting peaks of the wild-type and mutant alleles than that by the existing method (ΔTm ∼ 3°C) for specimens heterozygous for the 1298A>C polymorphism.
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