Sentence examples for improving potency and from inspiring English sources

Being the most clinically useful CCBs, 1,4-dihydropyridines (DHPs) attracted great interest in improving potency and selectivity.

A series of alkylaryl and sulfonylaryl groups, on the IDA basic scaffold, was investigated with the aim of improving potency and selectivity against MMPs involved in degenerative diseases.

A library of sulfonamide analogs has been designed and synthesized with the intent of examining the SAR of this series of compounds and improving potency and physicochemical properties as compared with lead compounds 1 and 2. At the end, we have achieved a thorough understanding of the structural features critical for future optimization work.

Use of structure activity (SAR) and structure property relationship (SPR) design criteria followed by in vivo evaluation of compounds in a mouse model focused on improving potency and establishing in vivo efficacy of analogues.

In addition, an enormous amount of kinase-targeting medicinal chemistry has been enabled by structural biology studies that can help elucidate the binding modalities of compounds and assist in improving potency and selectivity profiles by informing key contacts between inhibitor and target.

Taken together, the metrics indicate that although the LE and LLE fall for the tryptophan series, the LLE can be maintained in the sulfonamide series whilst improving potency and actually increasing LE, suggesting the sulfonamide series is more attractive in terms of their suitability toward development.

In addition, medicinal chemistry will be used to improve potency and specificity of RAD288 and RAD289.

Buoyed by fresh targets, improved potency, and a clinical trial about to begin, researchers are ready to prove that protein degraders can be more than a parlour trick.

Structure modifications were performed in order to improve potency and pharmacokinetic (PK) properties.

Further evaluations on both human and mouse 11β-HSD revealed that seven urea derivatives exhibited significant improved potency and selectivity.

These studies suggested that substitutions around the phenoxy ring of this scaffold can impart improved potency and selectivity for MEKK2.