Sentence examples for improving potency from inspiring English sources

Virtual screening identified fragments that could be fused into the core scaffold, exploiting additional binding interactions and thus improving potency.

Being the most clinically useful CCBs, 1,4-dihydropyridines (DHPs) attracted great interest in improving potency and selectivity.

A series of alkylaryl and sulfonylaryl groups, on the IDA basic scaffold, was investigated with the aim of improving potency and selectivity against MMPs involved in degenerative diseases.

A library of sulfonamide analogs has been designed and synthesized with the intent of examining the SAR of this series of compounds and improving potency and physicochemical properties as compared with lead compounds 1 and 2. At the end, we have achieved a thorough understanding of the structural features critical for future optimization work.

Most importantly, the current study provides insights on the utilization of systematic medicinal chemistry approaches to mitigate safety liabilities while improving potency during progression from an initial genotoxic hit, the benzothiazole N-oxides (BTOs) to the lead-like AMES negative, crowded benzothiazoles (cBTs).

To address this issue, we carried out a PET-specific structure activity relationship (SAR) effort with the goal of further improving potency while maintain other properties.

Drugs like Viagra help improve potency in those who have such problems after prostate surgery.

In addition, medicinal chemistry will be used to improve potency and specificity of RAD288 and RAD289.

Lehár, J. et al. Improved potency of cisplatin by hydrophobic ion pairing.

Two distinct pathways of immuno-modulation improve potency of p53 immunization in rejecting established tumors.

The elongated trifluoroethoxy analogue 32 showed improved potency on the mouse orthologue.