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However, the efficacy of HIV-1 inhibition by PA remains in submicromolar range, suggesting potential for improving its efficacy.
As gemcitabine typically only prolongs life by a few months, agents improving its efficacy are needed.
Understanding the structure/function of endostatin therefore will help in improving its efficacy to inhibit tumour growth.
In recent years, enormous efforts have gone into improving its efficacy, including biochemical modulation and changing the method of its administration.
To gain insight into the reaction rates and mechanism of persulfate decomposition in the subsurface, and to identify possible approaches for improving its efficacy, the decomposition of persulfate was investigated in the presence of pure metal oxides, clays, and representative aquifer solids collected from field sites in the presence and absence of benzene.
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Metoclopramide administered in high doses acquires the capacity to block 5HT3 receptors, which improves its efficacy but it has frequent side effects.
However, further improvement may help to improve its efficacy.
However, the activity of gemcitabine in pancreatic cancer remains modest and there is a clear need to improve its efficacy by combining it with other anticancer drugs.
Further studies to improve its efficacy and to compare it with existing salvage regimens are warranted.
The relative instability of endostatin may limit its usefulness as a cancer treatment; however, it has been documented that continuous infusion can improve its efficacy over bolus treatment (Kisker et al, 2001).
However, there continues to be a need for alternative docetaxel delivery systems to improve its efficacy.
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