We expect that the study of these differences will be fundamental in postulating, verifying and uncovering mechanisms of regulation, while simultaneously confirming or improving hypotheses derived through in silico predictions.
While model predictions need to be experimentally validated, models can substantially improve hypothesis generation and experimental planning.
More and higher quality data should lead to improved hypothesis testing and predictions, yet as the quantity and quality of the reporting data improve, predictions are needed less.
Moreover, HyBrow's ability to propose "improved" hypotheses is orthogonal to its conjecture validation mechanism, and is a property of many other systems (e.g., [17]).
Perhaps clustering of genes by expression pattern will yield improved hypotheses regarding shared regulation and function.
Then again, conservation data on the sequence level is very often available, and conservation of transcriptional modules [ 5] can help to improve hypotheses about transcriptional regulation.
An organism can adapt to a new environment by starting with a hypothesis about the environment, then testing it against new data and, based on the feedback, gradually improving the hypothesis by using an ecorithm, to behave more effectively.
So although scientists are continually refining and improving smaller hypotheses that are a part of evolutionary theory, evolution itself is far from a theory in crisis.
By incorporating the piecewise transverse slip profile and improving the hypotheses in the shear-compression failure model of BSP beams, a semi-empirical design formula was derived based on the force equilibrium of the beam segment outside the main diagonal crack, thus the shear capacity of BSP beams can be evaluated.
We believe that the ability to formally verify a biological model versus the laboratory observations offers great advantages in improving working hypotheses and suggesting new experimental directions that are likely to yield new findings.
