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Thus, optimization of pHIFU-treatment condition is important for improving delivery efficiency of nanoparticles or drugs to target tissue.
Therefore, clinicians currently have to choose between the removal of humidification (thus improving delivery efficiency but potentially exposing the patient to adverse side effects) or the retention of humidification (protecting the patient but compromising delivery efficiency).
Moreover, sonoporation has long been regarded as the main mechanism of improving delivery efficiency and it is necessary to optimize sonoporation protocols to obtain a higher transfection rate [ 13].
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Linear DNA traverses nucleopores efficiently [ 52] and may therefore improve delivery efficiency of RNAi expression cassettes.
Therefore, pHIFU can be a promising technique that improves delivery efficiency of nanoparticles and overcomes the current limitations of nanoparticle delivery, tissue penetration.
Furthermore, pHIFU treatment could improve delivery efficiency of theranostic materials to the target sites by an increasing extravasation from the vasculature and improving tissue penetration [17].
However, appropriate design or engineering of nanoparticles will be needed to improve delivery efficiency of antigen, adjuvant and therapeutics, resulting in eliciting antitumor immunity.
Nanoparticles (NPs) have been extensively investigated for applications in both experimental and clinical settings to improve delivery efficiency of therapeutic and diagnostic agents.
In this study, we reported a strategy to improve delivery efficiency of a long-circulation biomimetic photothermal nanoagent for enhanced photothermal therapy through selectively dilating tumor vasculature.
Censorship of the soldiers' mail continued through WWII, though the invention of Victory Mail improved delivery efficiency.
The interaction mechanism of carotenoid with lipid bilayer is one of the major concerns in improving the delivery efficiency of liposomes.
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