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At low doses the phytoestrogens, as ligands of ER, are likely to stimulate directly metabolic pathways providing and/or improving cell proliferation, in particular progression of cell cycle and apoptose inhibition.
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With increasing levels of porosity/interconnectivity, improved cell proliferation is obtained within the pores.
Consequently, the static mixer also improved cell proliferation with a significantly higher specific growth rate in round wells.
The results showed that the three lecithins (soya, rapeseed and salmon) improve cell proliferation at different concentration.
This altered cell adhesion behavior led to improved cell proliferation, migration and formation of capillary-like network in the hydrogel in vitro.
The HA TOBC Gel significantly improved cell proliferation as well as cell differentiation confirming the material as a potential candidate for use in bone tissue engineering scaffolds.
These results demonstrated that the apatite/collagen sponge composite coating could improve cell proliferation and ALP activity of the hybrid scaffolds and increase its hydrophilicity after hybridization.
The HA-deposited surface after nanotube formation on the Ti Nb Hf alloys should provide improved cell proliferation at a higher rate than on the nanotubular and bulk titanium alloy surfaces.
The incorporation of Ca-P nanoparticles significantly improved cell proliferation and alkaline phosphatase activity for Ca-P/PHBV scaffolds, whereas CHAp/PLLA nanocomposite scaffolds exhibited a similar level of cell response compared with PLLA polymer scaffolds.
The addition of SA to the medium improved cell proliferation and ECM synthesis on this biodegradable material, which leads to the formation of well organized, mechanical resistant tissue-engineered structure.
Therefore both cell line development and process development are trying to (a) improve cell proliferation to reduce lag-phase and achieve high number of cells; (b) delay cell death to prolong the production phase and improve culture longevity; (c) and finally, increase qP.
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