Sentence examples for improving affinity for from inspiring English sources

Because none of the replacements acted as a switch that impaired binding to some sequences while improving affinity for others, multiple replacements were necessary to achieve the derived specificity and affinity.

The generated PI3Kα mutants exhibit significantly improved affinity for selective ATR inhibitors in multiple chemical classes.

The variant DigA16/19, which carries several new mutations, exhibits clearly improved affinity for digoxigenin, with KD=12.4 nM.

HwTx-IV and mHwTx-IV exhibited weak affinity for lipid membranes, whereas gHwTx-IV showed improved affinity for the model membranes studied.

Further experiments implicated other H1N1 genes in the enhancement of mammal-to-mammal transmission, including nucleoprotein (NP), neuraminidase (NA), and matrix (M), as well as mutations in H5 HA that improve affinity for human-like airway receptors.

The previously reported analog 6 remains as the only variant that exhibits improved affinity for the d-Ala-d-Lac sequence and acceptable affinity for the d-Ala-d-Ala sequence.

With such an approach, these composite layers can be designed to have improved affinity for cells and to exhibit increased gene transfer efficiency over that of conventional lipid transfection reagents.

In contrast, constructs A1B2, A1B2D1W and A1B2D1R displayed binding properties with improved affinity for 5-HT3R ligands.

Our FA results show improved affinity for all three engineered constructs.

Relative to AG99, many of these compounds showed improved affinity for EGFR, exemplified by AG538 (IC50 = 0.37 μM, Chart 1).

Here, a biparatopic anti-EFGR nanobody showed an improved affinity for its target and an inhibition of tumor proliferation [57].