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This improves the affinity and confers specificity to the binding.
It improves the affinity of SERCA2a for calcium by activating a cAMP-dependent protein kinase of PLN.
Binding to the Ku proteins improves the affinity of DNA-PKcs for DNA ends about 100-fold [37].
Because complex formation improves the affinity and sequence selectivity of Hox proteins, we asked if Hoxa2/TALE complexes occupy different genomic regions relative to TALE proteins alone.
The occupancy of one site is sufficient for activity, whereas occupancy of the second site improves the affinity to both ATP and ADP.
The addition of the N-terminal coiled coil in NEMOwNcc improves the affinity to <1 μM (980 ± 20 nM), and the C terminal coiled coil in NEMOwCcc (150 ± 6 nM) restores binding to the level of our control GST-NEMO(1 196) (168 ± 4 nM).
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Tannins play very important role in dyeing with natural dyes by improving the affinity of fibres towards different dyes.
Biol.], we describe engineering efforts to improve the affinity of mAb 5D3D11, a first step towards such goal.
In order to improve the affinity and activity of these HDACIs, twenty seven isoferulic acid derivatives were described herein.
In particular, GO has unique chemical functional groups (epoxy bridges, hydroxyl groups, pairwise carboxyl groups (carboxyl and carbonyl)) which improve the affinity and covalent bonding of biomolecules.
To improve the affinity, yeast display of the 2C TCR was used to engineer two mutant TCRs that exhibited higher affinity for F5R Ld (KD = 1.2 and 6.3 μM).
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