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A thioesterase with altered specificity added to the strain improves specificity for specific fatty acid chain lengths.
In the reference capacity approach, the use of cost functions improves the reliability and transparency of the calculations and accounts for capacity variation, and since capacity is required in the assessment, it improves specificity since this term must be specified.
We have found that the error beta binomial distribution's mean (given by α/ provides a good alternative threshold that consistently improves specificity without undue loss of sensitivity (or vice versa, when the positive class is larger)a.
Some, like Harvard University geneticist George Church, have shown that knocking out one of the two DNA cutting sites in Cas9 to create a so-called nickase, and pairing those molecules using two closely spaced guide RNAs, dramatically improves specificity.
The assay significantly improves specificity over culture, but sensitivity of sodC compared to culture is difficult to determine due to the lack of culture-positive clinical specimens received.
In a survey of methods that estimate differential expression, Smyth [37] showed that empirical Bayes improves specificity while having very little effect on sensitivity.
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Moreover, in order to improve specificity, targeting photosensitizers specifically to a certain type of microorganisms was tested.
Age-specific reference ranges improved specificity in older men (49%) but decreased sensitivity (70%), with an LR+ of 1.38.
The MSN were further functionalized with a peptide found to bind specifically to bladder cancer cells, thus improving specificity.
Future improvements will include the incorporation of targeted imaging contrast agents to improve specificity for imaging tumours.
Improved specificity and diagnostic capability can be achieved by developing assays that detect cancer-specific alterations of glycoprotein glycosylation.
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