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Other evidence that CR may increase human lifespan can be found in ongoing studies showing that CR improves markers of disease risk and health in rhesus monkeys [17], [18].
Moreover, CR in human beings improves markers of cardiovascular aging, and rejuvenates the skeletal muscle transcriptional profile.
This study assessed whether preoperative perhexiline improves markers of myocardial protection in patients undergoing coronary artery bypass graft surgery and analysed its effect on the myocardial metabolome.
Two recent studies by Lee and Ko [ 148] and Shin et al. [ 149] show that metformin treatment of mice on a high-fat diet improves markers of metabolic disorders and provokes an alteration in the structure of faecal microbiota towards that of mice fed a normal chow diet.
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In addition to improving markers of metabolic syndrome, high intake of dietary fiber is associated with improved diet quality.
Ascorbic acid did not improve markers of endothelial function or attenuate the inflammatory response markers in this study.
Caloric restriction has been shown to be a successful weight loss intervention that may also improve markers of oxidative stress [106 109].
Resveratrol supplementation has been reported to improve markers of vascular function, but poor bioavailability of the parent compound is thought to limits its use.
Although various genetic and pharmacologic interventions can improve markers of cardiac function in heart failure, prolongation of survival is the gold standard outcome.
It is possible that noncellular markers in blood, particularly of circulating DNA, may act as improved markers of residual disease.
Addition of rVIIa therefore appears to improve markers of global haemostasis in this model of large volume fluid replacement.
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