We found significant improvements in sleep hygiene, sleep quality as well as daytime symptoms such as a reduction in daytime sleepiness and sedentary/light activity, following the intervention.
Prolonged-release melatonin improved sleep maintenance in comparison with placebo, as indicated by improvements in sleep efficiency, wake after sleep onset, and number of awakenings.
Patients showed significant improvements in sleep onset latency, wake time after sleep onset, sleep efficiency, insomnia severity, and dysfunctional sleep beliefs from pre- to post-treatment.
Cyclobenzaprine treatment resulted in moderate improvement in sleep, modest improvement in pain, and no improvement in fatigue or tender points [ 27].
Also, it is unclear what improvements in sleep measures indicate in healthy volunteers without sleep disturbances.
Participants who practiced Tai Chi saw greater improvements to sleep quality, diminished fatigue, and relief from depressive symptoms, compared to the sleep-education control group.
Parallel changes would suggest a possible relationship between improvement in sleep variables and improvement in clinical scores.
To determine if melatonin improves tinnitus and if this improvement is related to improvement in sleep.
But this could be from estrogen-induced improvements in sleep patterns, rather than the direct effects on the brain.
Interestingly, antidepressants that cause phase delays have been associated with improvements in sleep continuity (Duncan 1996).
