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Refinements and optimization of high-throughput docking methods have lead to improvements in reproducing experimental data and in hit rates obtained, validating their use in hit identification.
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In all the experiments reported here, no trouble was observed in reproducing additional crystals for improvement or data collection.
These irradiance models are remarkably successful in reproducing the observed total and spectral irradiance, although further improvements are still possible.
The improvements considerably increase the accuracy of the pressure gradient predictions, without affecting the model's capability in reproducing the other features of these flows of most engineering interest, namely solid volume fraction distribution and velocity distribution.
However, recent investigations failed to reproduce performance improvements in experts, leaving it uncertain whether robust benefits exist.
At the same time, improvements in casting allowed dinosaur skeletons to be reproduced and shipped across the world for display in far-flung museums, bringing them to the attention of a wider audience; Diplodocus was the first such dinosaur reproduced in this way.
No single mutation was solely responsible for the improvements in tolerance, and all five were needed to reproduce the levels observed in evolved strains.
Previous studies of permanent BiV pacing have reported acute improvements in haemodynamic function [ 1– 4] but attempts to reproduce these findings acutely after cardiac surgery have produced mixed results [ 5– 10].
Whereas animal studies have reported improvements in load-to-failure, early clinical studies did not reproduce this effect [13], [14], [17].
We found that our method was able to reproduce the earlier observations with significant improvements in depth of coverage for validated or expected biological themes, but also produced additional insights that make biological sense.
Remarkable improvement in motor activity was reproduced by infection of AAV1-HMGB1-GFP (Supplementary Fig S8C) when we similarly injected AAV-HMGB1-GFP at 5 weeks of age and tested the motor function of Atxn1-KI mice from 9 to 12 weeks of age.
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