Sentence examples for improvements in potency from inspiring English sources

Here, molecular docking was used to predict improvements in potency and solubility of new derivatives of compound 1 in inhibiting edema toxin (ET -catalyzed stimulation of cyclic AMP production in murinET -catalyzedcrophage cellstimulation7).

Improvements in potency could further make cancer cell vaccines a useful and safe method for preventing cancer recurrence after resection.

Another objective of this study was to determine whether improvements in potency and selectivity of the parent compound (76) could be achieved by examining structurally similar compounds.

Pivalate (21, GI50 = 7.3 nM), benzoyl (22, GI50 = 15 nM), and methoxymethyl (23, GI50 = 8.2 nM) showed similar but somewhat diminished improvements in potency.

Preliminary modification of LDS21 R-groups was undertaken to assess improvements in potency with reference to predicted interactions with the p7 structure/channel model (Fig. 5C).

Highly successful improvements in potency, up to 50-fold increases in IC50, have been achieved by constructing bridges between distal centers in PTX that imitate the conformer of the electron crystallographic binding pose.

Introduction of a single methyl branch at the 2-position of the side chain as in compound 8 slightly improved activity over that of the unbranched compound 26, and significant improvement in potency was observed with the addition of a second methyl group at this position as in the neopentyl group of compound 27 (omadacycline).

"My feeling is that radiation tends to offer some improvement in potency preservation".

Compared to compound 1, PF-05270430 achieved ~4× improvement in potency (IC50 = 0.5 nM) without compromising selectivity and other properties.

Employing this strategy, a >400× improvement in potency over the initial hit was realized in rapid fashion.

Liver exposure data indicate that the improvement in potency is predominantly due to increased metabolic stability of the siRNA conjugates.