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Unknown potential long-term safety issues with new classes of drugs could shift the perception of an otherwise-accepted surrogate, eliciting a preference for final outcome studies to confirm that the expected improvements in efficacy also improved overall safety (such as new drug classes of antihypertensives or oral diabetic agents).
This will contribute to improved overall patient survival and better quality of life through significant improvements in efficacy and the minimization of harmful side effects.
We agree that pharmaceutical companies need to show real improvements in efficacy when introducing new medicines to market.
The ruling is important, nonetheless, because it establishes a limited precedent that requires drug companies to show real improvements in efficacy before they can get patent protection on updates to existing drugs in India.
Also diversifying the components of the combinations may allow for improvements in efficacy by attacking the bacteria from different approaches simultaneously.
Biodegradable hydrogels can deliver therapeutic payloads with great potentials in EMR and endoscopic submucosal dissection (ESD) to yield improvements in efficacy and foster mucosal regeneration.
Similar(37)
The results on homologation of the SCH28080 by varying the linker chain length suggested the improvement in efficacy.
In conclusion, this pooled analysis documents a substantial improvement in efficacy in de novo RTx recipients receiving EC-MPS vs MMF with concomitant cyclosporine and steroid therapy.
An improvement in efficacy was observed with increasing benznidazole doses; cure was verified in 28.6% (75 mg/kg), 57.1% (100 mg/kg) and 80% (300 mg/kg).
The clinical trials of experimental nanomedicine have experienced unexpected adverse effects with modest improvement in efficacy when compared to current frontline therapy.
A control conjugate without PEG demonstrated no improvement in efficacy over untargeted CPT emphasizing the importance of spacer between the anticancer compounds and targeting moiety.
More suggestions(14)
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