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The resultant cardiac repair further promotes the significant improvement of heart function.
Generation of "strong-contracting and fast-conducting" cardiac tissue patches capable of electromechanical coupling with host myocardium could allow efficient improvement of heart function without increased arrhythmogenic risks.
The observed small improvement of heart function in such experiments is likely due to secretion of factors from the transplanted cells that positively influence vascularization and heart remodelling.
Elucidating the major mechanism underlying the improvement of heart function by G-CSF treatment will require much more investigation.
To date, numerous studies have been reported demonstrating improvement of heart function in support of this goal [ 1, 2].
Finally, ciglitazone inhibited perivascular and interstitial fibrosis in mice that underwent aortic banding, with concomitant improvement of heart function.
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Even the normal mice, however, showed some improvement on measures of heart function and bone loss.
Such treatments have failed to demonstrate any improvement on heart function as compared to control group [ 67].
The results were mixed: some studies found moderate improvements in a few measures of heart function, but none were able to show a clear health benefit.
Noninvasive methods permit multiple measurements of heart function, allowing the progression of post-infarction remodeling to be followed and cell-mediated improvements to be identified.
ECMO maintains tissue oxygenation pending recovery of heart function.
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