Sentence examples for improvement of compounds from inspiring English sources
These findings provide guidance for the design and improvement of compounds with DAT activity, which is important for the development of a treatment of cocaine addiction and certain neurological disorders.
Improvement of compound 13 hydrophobic character by addition of an aromatic ring substituent resulted in entropic optimization, reflected on a thermodynamic discrimination profile characteristic of high affinity ligands.
Maintenance of the safety and integrity of sterile compounded drugs in the United States demands a thorough review and improvement of compounding pharmacy regulatory practices.
Thus, there should be significant potential for further improvement of compound optimization efforts by taking activity cliff information from data mining into consideration.
This collection showcases some of the most recent advances in organic synthesis, biocatalysis and -chemistry geared towards discovery and improvement of bioactive compounds, which have been published in Nature Communications.
LC-MS identification of a mono-hydroxylated metabolite found in the RLM incubation of 4 3 provided an impetus for further improvement of the compound.
Rational improvements to compounds of this class resulted in single-digit nanomolar enzyme and cellular activity against PLK1, and oral bioavailability.
These methods largely address improvements in separation of compounds in GC.
These results demonstrated that metabolic profiling analysis could be successfully applied to the rational guidance of medium optimization and the productivity improvement of value-added compounds.
The qualitative and quantitative improvement of biologically active compounds by plant cell, tissue and organ culture have been used as an alternative source for the production of important bioactive secondary metabolites using different strategies of metabolic engineering.
